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References vetchiana Category:Flora of Central America Category:Flora of South America Category:Flora of the Caribbean Category:Flora of Mexico Category:Plants described in 1754Engineering the protein structure of the serine protease inhibitor pin1 using combinatorial library approaches. Protease-activated receptor-1 (PAR-1) is a protease-activated G-protein-coupled receptor (GPCR) that activates platelets, neurons and endothelial cells. The potent and specific human PAR-1 activator peptide SFLLRN induces a transient increase in intracellular Ca(2+) that is associated with PAR-1 internalization. The PAR-1 peptide undergoes self-cleavage to form a 12-residue peptide that binds to PAR-1 and triggers PAR-1 receptor internalization and activation. The active region of the PAR-1 peptide lies in its C-terminal region, where it interacts with the first extracellular loop of PAR-1. 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